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Bioanalytical Services at Cores

Cores can build on the expertise of a large team of specialised researchers in the fields of virology, immunology, epidemiology and vaccines. Our ISO certified state of the art laboratory in Deventer, The Netherlands, is spreading across 5750 m2 and is equipped with best in class equipment in all relevant fields, such as microbiology, molecular biology, immunology or haematology.  

With a history dating back more than a century, and origins in the world of veterinary sciences, we offer a broad range of bioanalytical services - at GLP or GCP standards - to help you with vaccine development in the broadest sense of the word. But you can also rely on us for clinical sample analysis on blood or tissue samples taken during your clinical trials. 

Depending on your needs we can run low volume, in-depth analyses as well as quick, high-throughput methods. Apart from our standardized, validated assays we offer customized protocols as well as new assay development.

In short, our laboratory offers a diverse range of specialised services and expertise, combining advanced technologies and validated protocols to support research, vaccine development, clinical trials and product design.  

 

Virus and Pathogen Detection

Our laboratory offers Tissue Culture Infectious Dose 50 (TCID50) testing to semi quantify infectious virus particles. 

Using serial dilutions of your sample, we inoculate cultured cells and monitor for cytopathic effects (CPE). The TCID50 value is calculated to reflect the dilution at which 50% of wells exhibit infection. 

This method is ideal for assessing viral infectivity, evaluating vaccine production, and ensuring accurate viral quantification.  

Rapid pathogen detection and molecular diagnostics with customizable assays.

We specialize in Virus Neutralization (VN) testing using the advanced Microneutralisation assay (MNA). 

This method combines traditional neutralization assays with highly sensitive detection of antibody responses at the cellular level. 

By incubating the virus with serial dilutions of serum or antibodies and introducing the mixture to susceptible cells in a media which inhibits 3 dimensional growth, we can produce spots of infected cells through Immunostaining (IPMA). Those spots can be easily quantified using our CTL Immunospot and in turn is used to determine neutralizing titers and identify specific immune responses. This service is critical for vaccine evaluation, therapeutic antibody development, and immune response research.

Our Hemagglutination Inhibition (HI) testing service helps measure antibody responses to hemagglutinating viruses, such as influenza.  

This assay determines the ability of antibodies to prevent the clumping of red blood cells caused by viral hemagglutinin proteins.  

With expertise in influenza characterization and serological analysis, we provide accurate HI titers to support vaccine development and research. 

Including PCR and multiplex assay development for genotyping and strain-specific tests.

Immunology and Clinical Assays

Detection and quantification of antigens and antibodies, with method development available. 

Quantification of innate and adaptive immune responses.

Genomics and Microbiology

Unlock the full genetic blueprint of viruses with our Whole Genome Sequencing (WGS) services using Oxford Nanopore Technology (ONT). This cutting-edge platform enables rapid and high-resolution sequencing of viral genomes, delivering comprehensive data for strain identification, mutation analysis, and outbreak tracking. Nanopore sequencing provides flexibility and scalability, making it an ideal solution for real-time genomic insights into viral evolution and resistance mechanisms. 

MALDI-TOF Mass Spectrometry

Our bacteriological laboratory offers rapid and reliable identification of bacteria using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS).  

A protein mass spectrum is being generated from the ‘unknown’ bacterium and then, the extensive reference database automatically is being searched for a matching ‘fingerprint’. From taking some colony material from ‘unknown’ bacteria up to their identification results, it takes only a few minutes. This way of rapid and accurate identification of bacteria, with a high-throughput, enables us to streamline diagnostics and research workflows.

Fourier Transform Infra-Red Spectroscopy  

For more in-depth characterization, we offer bacterial strain typing based on Fourier Transform Infra-Red Spectroscopy (FTIR).  

Using this technique, an infra-red spectrum of a bacterium is being generated, reflecting the biochemical composition of the bacterial cell. This spectrum can be regarded as a biochemical ‘fingerprint’ of the bacterium. Using specific software, infrared spectra of different isolates of the same bacterial species can be compared to each other and classified into different clusters. Our service of bacterial strain typing by using FTIR analysis provides a rapid procedure for e.g. source tracking in outbreak investigations and quality monitoring - supporting advanced diagnostics and research.  

Our laboratory is well experienced in in-vitro antimicrobial susceptibility testing by determination of Minimum Inhibitory Concentrations (MICs) of antimicrobials using broth microdilution. Information on the susceptibility profile of bacterial isolates allows more prudent use of antimicrobial drugs and results are being used for monitoring purposes. In addition to antibiotics, we have experience in testing the antimicrobial activity of alternatives to antibiotics. Our MIC testing supports clinical, pharmaceutical, and research applications. 

Other services

Besides testing of clinical samples, or other laboratory services, Cores can also support your research through the following.

Animal models for vaccine and drug development

Efficacy, Challenge or Mucosal immunity studies or testing of alternative administration routes and methods.



Disease modelling, Histology and Pathology

In house histology and pathology.





R&D Support

Joint development of study designs, partnering of our specialists in your research projects




Interested in our services? Get in touch!

Dou you want to talk about your project or are you curious to find out how we can help you to advance your project. Contact us today!

 

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More about Cores and the services we offer

Explore our organization and the services we offer to learn how we can support your research needs. Or contact us directly to discuss in person how we can help you on your project. 


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